Basophils and allergic inflammation
نویسندگان
چکیده
منابع مشابه
Basophils are essential initiators of a novel type of chronic allergic inflammation Short title: basophils initiate chronic allergic inflammation
Kazushige Obata, Kaori Mukai, Yusuke Tsujimura, Kenji Ishiwata, Yohei Kawano, Yoshiyuki Minegishi, Naohiro Watanabe, and Hajime Karasuyama Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan, Department of Tropical Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461...
متن کاملMast cells and basophils: a potential link in promoting angiogenesis during allergic inflammation.
Mast cells and basophils are granulated metachromatic cells which possess complex and partially overlapping roles in acquired and innate immunity, including both effector and regulatory activities. Mast cells and basophils cooperate in exacerbating and/or modulating inflammation as well as in mediating subsequent tissue repair. Mast cells release a series of potent proangiogenic molecules durin...
متن کاملIL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma
BACKGROUND The alarmin cytokines IL-25 and IL-33 are key promoters of type 2 inflammation. Basophils respond to alarmin cytokines, however the relationship of these cytokines with basophil activation and recruitment in human studies of allergic asthma has not been well characterized. This study investigated the effect of IL-25 and IL-33 on basophils in a model of allergic asthma. METHODS 10 m...
متن کاملBasophils as Key Regulators of Allergic Inflammation and Th2-type Immunity
Basophils have long been suspected as playing more than a bystander role in initiating and maintaining allergic disorders, despite their relatively low numbers compared with other effector cells, such as mast cells and eosinophils. In vitro studies clearly demonstrated their propensity to generate proallergic cytokines, such as interleukin 4 and interleukin 13, as well as histamine and leukotri...
متن کاملBasophils are essential initiators of a novel type of chronic allergic inflammation.
Basophils represent less than 1% of peripheral blood leukocytes and have often been considered as minor and possibly redundant circulating mast cells. The recent finding that basophils readily generate large quantities of T helper 2 (Th2) cytokines such as IL-4 provided new insights into the possible role of basophils in allergic disorders and immunity to pathogens. However, in-depth studies on...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2013
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2013.07.046